It appears you have not yet registered with the CAT Forums. To register please click here...

Go Back   Cat Forums - I-Love-Cats - your Ultimate Cat Forum > General Cat Discussion > Cat Product Reviews > Cat Book Reviews

Featured Photos

LinkBack Thread Tools Display Modes
Unread 09-29-2006   #1 (permalink)
Supreme Cat Lover!
admin's Avatar
Join Date: Sep 2006
Posts: 13,433
Thanks: 0
Thanked 22 Times in 15 Posts
My Mood: Breezy
admin has disabled reputation
Send a message via twitter to admin
Default Effect of ramipril on left ventricular mass, diastolic function, and neurohormones in feline hypertrophic cardiomyopathy -- Dissertation

Hypertrophic cardiomyopathy (HCM) is the most common heart disease of cats, and has been found to be an autosomal inherited defect with incomplete penetrance in Maine Coon cats. Affected cats develop concentric left ventricular hypertrophy, myocardial fibrosis, and often have diastolic dysfunction. Congestive heart failure or arterial thromboembolism are potential devastating sequelae to severe HCM. In this study, the technique of cardiac magnetic resonance imaging (cMRI) for quantification of LV mass was validated in normal cats, and used cMRI for LV mass quantification in cats affected with HCM. We also identified that gradient echo cMRI, using Simpson\'s rule, is not an effective method for identification of diastolic function compared to Doppler tissue imaging echocardiography in cats with HCM. Likewise, contrast enhancement cMRI does not appear to be a useful technique to non-invasively quantify myocardial fibrosis in cats with HCM. This study evaluated the effects of ramipril, an angiotensin converting enzyme inhibitor on left ventricular mass, diastolic function, delayed contrast enhancement cMRI, plasma neurohormones (brain natnuretic peptide and aldosterone), and systolic blood pressure. 26 cats were treated with ramipril or placebo in a blinded fashion for one year. There was no statistical or clinical difference in any measured parameters between cats treated with ramipril versus cats treated with placebo. In conclusion, while the current study lacked statistical power to find differences in the measured parameters to be statistically significant, the use of ramipril in asymptomatic cats with moderate to severe HCM does not appear to cause clinically relevant changes in left ventricular mass, diastolic function, or plasma neurohormones.

admin is offline  
Digg this Post!Add Post to del.icio.usBookmark Post in TechnoratiFurl this Post!
Reply With Quote

Sponsored Cat Content

cats , fashion , found , hyper , maine coon

Sponsored Cat Links

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are On

Similar Threads
Thread Thread Starter Cat Forum Replies Last Post
Cat On Stage Left an Alice Nestleton Mys admin Cat Book Reviews 0 09-29-2006 08:00 PM
The Cat That Was Left Behind admin Cat Book Reviews 0 09-29-2006 08:00 PM
Cat On Stage Left an Alice Nestleton Mys admin Cat Book Reviews 0 09-29-2006 07:59 PM
The Cat That Was Left Behind admin Cat Book Reviews 0 09-29-2006 07:59 PM

All times are GMT -4. The time now is 03:06 PM.

Powered by vBulletin Version 3.8.5
Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.

Sitemap: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28